Sign in →

Test ID SYPHT Syphilis Total Antibody with Reflex, Serum


Specimen Required


Collection Container/Tube: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum


Useful For

Aid for the diagnosis of recent or past Treponema pallidum infection

 

Routine prenatal screening

 

This test is not offered as a screening or confirmatory test for blood donor specimens.

 

This test is not useful for diagnosis of congenital syphilis.

Highlights

This testing should be used to assess for recent or past infection with Treponema pallidum or for routine prenatal screening.

 

Syphilis screening at Mayo Clinic and Mayo Clinic Laboratories is performed using the reverse screening algorithm.

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
RPRS RPR Screen w/ Reflex, S No No
RTPPA Syphilis Ab, TP-PA, S Yes, (Order TPPA) No
RRPRQ RPR Titer, S No No
SYPNB Syphilis Total Ab Bill Only 1 No, (Bill Only) No
SYPPB Syphilis Total Ab Bill Only 2 No, (Bill Only) No

Testing Algorithm

If syphilis total (SYPHT) is nonreactive, billing will be captured under SYPNB.

 

If syphilis total (SYPHT) is reactive or equivocal, then rapid plasma reagin (RPRS) will be performed. Billing will be captured under SYPPB.

 

If RPRS is reactive, then RPR titer (RRPRQ) will be performed at an additional charge.

 

If RPRS is nonreactive, then syphilis antibody (RTPPA) will be performed at an additional charge.

 

See Syphilis Serology Algorithm in Special Instructions.

Special Instructions

Method Name

SYPHT, RPRS: Multiplex Flow Immunoassay

RRPRQ: Flocculation/Agglutination

RTPPA: Particle Agglutination

Reporting Name

Syphilis Total Ab w/ Reflex, S

Specimen Type

Serum

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

SYPHILIS TOTAL ANTIBODY

Nonreactive

 

RAPID PLASMA REAGIN SCREEN

Nonreactive

 

RAPID PLASMA REAGIN TITER

Negative

 

SYPHILIS ANTIBODY, TP-PA

Negative

 

Reference values apply to all ages

Day(s) and Time(s) Performed

Monday through Saturday; 9 a.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86780-when SYPHT result is nonreactive

0064U-when SYPHT result is reactive or equivocal

86780-Syphilis Antibody by TP-PA (if appropriate)

86593-Rapid Plasma Reagin Titer (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SYPHT Syphilis Total Ab w/ Reflex, S 47236-5

 

Result ID Test Result Name Result LOINC Value
SYPHT Syphilis Total Ab w/ Reflex, S 47236-5

NY State Approved

Yes

Forms

If not ordering electronically, complete, print, and send a Microbiology Test Request (T244) with the specimen.