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Test ID SZMON Sezary Monitoring Flow Cytometry, Blood

Useful For

Monitoring response to therapy in patients with previously diagnosed Sezary syndrome or mycosis fungoides

Additional Tests

Test ID Reporting Name Available Separately Always Performed
FIRST Flow Cytometry, Cell Surface, First No Yes
ADD1 Flow Cytometry, Cell Surface, Addl No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
FCIMS Flow Cytometry Interp, 9-15 Markers No No
FCINS Flow Cytometry Interp,16 or greater No No

Testing Algorithm

Sezary panel is ordered in cases with previously diagnosed Sezary syndrome or cutaneous T-cell lymphoma (CTCL) with peripheral blood involvement. For cases without a previously confirmed diagnosis or previously performed immunophenotyping at our laboratory, the ordered test will be changed to SZDIA / Sezary Diagnostic Flow Cytometry, Blood, which includes a triage panel to exclude a B-cell lymphoproliferative disorder and a Sezary panel.

 

The panel is charged based on number of markers tested (FIRST for first marker, ADD1 for each additional marker). In addition, reflex testing may occur to fully characterize a disease state or clarify any abnormalities from the screening test. Reflex tests will be performed at an additional charge for each marker tested (ADD1 if applicable).

Method Name

Immunophenotyping 

Reporting Name

Sezary Monitoring Flow Cytometry, B

Specimen Type

Whole blood


Ordering Guidance


This test is for monitoring response to therapy in patients who have been diagnosed with Sezary syndrome or mycosis fungoides. For patients who do not have a diagnosis of Sezary syndrome, SZDIA / Sezary Diagnostic Flow Cytometry, Blood is the appropriate test to order.



Specimen Required


Collection Container/Tube:

Preferred: Yellow top (ACD)

Acceptable: Lavender top (EDTA), green top (heparin)

Specimen Volume: 6 mL

Collection Instructions:

1. Send in original tube. Do not transfer blood to other containers.

2. Label specimen as blood.


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole blood Ambient (preferred) 72 hours
  Refrigerated  72 hours

Reference Values

An interpretive report will be provided. This test will be processed as a laboratory consultation. An interpretation of the immunophenotypic findings and, if available, morphologic features will be provided by a board-certified hematopathologist for every case.

Day(s) Performed

Monday through Saturday

Report Available

1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed using an analyte specific reagent. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

88184-Flow cytometry; first cell surface, cytoplasmic or nuclear marker x 1

88185-Flow cytometry; additional cell surface, cytoplasmic or nuclear marker (each)

88188-Flow Cytometry Interpretation, 9 to15 markers (if appropriate)

88189-Flow Cytometry Interpretation, 16 or more markers (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SZMON Sezary Monitoring Flow Cytometry, B In Process

 

Result ID Test Result Name Result LOINC Value
CK130 Sezary Monitoring No LOINC Needed
CK131 Final Diagnosis 50398-7
CK132 Special Studies 30954-2
CK133 Microscopic Description 22635-7

NY State Approved

Yes

Forms

If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.