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Test ID TICKS Tick-Borne Disease Antibodies Panel, Serum

Useful For

Evaluation of the most common tick-borne diseases found in the United States, including Lyme disease, human monocytic and granulocytic ehrlichiosis, and babesiosis


Evaluation of patients with a history of, or suspected, tick exposure who are presenting with fever, myalgia, headache, nausea, and other nonspecific symptoms


Seroepidemiological surveys of the prevalence of the infection in certain populations

Method Name

EHRC, ANAP, BABG: Immunofluorescence Assay (IFA)

LYME: Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

Tick-Borne Ab Panel, S

Specimen Type


Ordering Guidance

During the acute phase of an Anaplasma phagocytophilum or Ehrlichia chaffeensis infection, serologic tests are often nonreactive; polymerase chain reaction (PCR) testing is available to aid in the diagnosis of these cases; see EHRL / Ehrlichia/Anaplasma, Molecular Detection, PCR, Blood.

Specimen Required

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.

Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 10 days
  Frozen  14 days

Reference Values

Ehrlichia chaffeensis (HME) ANTIBODY, IgG


Reference values apply to all ages.


Anaplasma phagocytophilum ANTIBODY, IgG


Reference values apply to all ages.


Babesia microti IgG ANTIBODIES


Reference values apply to all ages.




Reference values apply to all ages.

Day(s) Performed

Monday through Friday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information


86666 x 2


86617 x 2-Lyme disease Western blot (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TICKS Tick-Borne Ab Panel, S 87547-6


Result ID Test Result Name Result LOINC Value
81157 Anaplasma phagocytophilum Ab, IgG,S 23877-4
81128 Babesia microti IgG Ab, S 16117-4
81478 Ehrlichia Chaffeensis (HME) Ab, IgG 47405-6
LYME Lyme Disease Serology, S 20449-5

Test Classification

See Individual Test IDs

Profile Information

Test ID Reporting Name Available Separately Always Performed
EHRC Ehrlichia Chaffeensis (HME) Ab, IgG Yes Yes
ANAP Anaplasma phagocytophilum Ab, IgG,S Yes Yes
BABG Babesia microti IgG Ab, S Yes Yes
LYME Lyme Disease Serology, S Yes Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
LYWB Lyme Disease Ab, Immunoblot, S Yes No

Testing Algorithm

If the Lyme disease screen result is positive or equivocal, then Lyme disease antibody confirmation by immunoblot will be performed at an additional charge.


For more information see Acute Tick-Borne Disease Testing Algorithm

Report Available

2 to 4 days

NY State Approved