Test ID TOSU Targeted Opioid Screen, Random, Urine
Additional Testing Requirements
In most cases, no additional testing is needed after the qualitative targeted opioid test is performed if the parent/metabolites found are consistent with the patients prescribed medications. However, if unexpected opioid parent/metabolites are found, confirmatory testing can be requested at an additional charge.
Specimen Required
Supplies: Aliquot Tube, 5 mL (T465)
Collection Container/Tube: Plastic urine container
Submission Container/Tube: Plastic, 5-mL tube
Specimen Volume: 3 mL
Collection Instructions:
1. Collect a random urine specimen.
2. No preservative
Useful For
Determining compliance or identifying illicit opioid drug use using urine specimens
This test is not intended for employment-related testing.
Highlights
This test uses high-resolution accurate mass spectrometry to identify 33 different opioids and/or metabolites where immunoassays are not adequate
This test offers lower detection limits than previous Mayo Clinic Laboratories-offered screens
This test has the ability to detect "spiked" samples
Profile Information
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
LPPO | List prescribed opioids | No | Yes |
TOPSU | Targeted Opioid Screen, U | No | Yes |
Method Name
Liquid Chromatography-Tandem Mass Spectrometry, High-Resolution Accurate Mass (LC-MS/MS HRAM)
Reporting Name
Targeted Opioid Screen, USpecimen Type
UrineSpecimen Minimum Volume
1 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Urine | Refrigerated (preferred) | 14 days | |
Frozen | 28 days | ||
Ambient | 72 hours |
Day(s) and Time(s) Performed
Monday through Friday; Varies
Performing Laboratory

Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
80364 (G0480 if appropriate)
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
TOSU | Targeted Opioid Screen, U | 95796-9 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
LPPO | List prescribed opioids | 29305-0 |
42323 | Codeine | 19411-8 |
42324 | Codeine-6-beta-glucuronide | 89310-7 |
42325 | Morphine | 19597-4 |
42326 | Morphine-6-beta-glucuronide | 89308-1 |
42327 | 6-monoacetylmorphine | 19321-9 |
42328 | Hydrocodone | 19482-9 |
42329 | Norhydrocodone | 89304-0 |
42330 | Dihydrocodeine | 19446-4 |
42331 | Hydromorphone | 19486-0 |
42332 | Hydromorphone-3-beta-glucuronide | 89309-9 |
42333 | Oxycodone | 19642-8 |
42334 | Noroxycodone | 89303-2 |
42335 | Oxymorphone | 19646-9 |
42336 | Oxymorphone-3-beta-glucuronide | 89301-6 |
42337 | Noroxymorphone | 89302-4 |
42338 | Fentanyl | 59673-4 |
42339 | Norfentanyl | 43199-9 |
42340 | Meperidine | 19532-1 |
42341 | Normeperidine | 27920-8 |
42342 | Naloxone | 42618-9 |
42343 | Naloxone-3-beta-glucuronide | 89307-3 |
42344 | Methadone | 19550-3 |
42345 | EDDP | 93495-0 |
42346 | Propoxyphene | 19429-0 |
42347 | Norpropoxyphene | 19632-9 |
42348 | Tramadol | 19710-3 |
42349 | O-desmethyltramadol | 86453-8 |
42350 | Tapentadol | 72485-6 |
42351 | N-desmethyltapentadol | 89306-5 |
42352 | Tapentadol-beta-glucuronide | 89300-8 |
42353 | Buprenorphine | 93494-3 |
42354 | Norbuprenorphine | 82371-6 |
42355 | Norbuprenorphine glucuronide | 89305-7 |
65059 | Opioid Interpretation | 69050-3 |
NY State Approved
YesForms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.