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Test ID TSTGP Tissue Transglutaminase Antibodies, IgA and IgG Profile, Serum

Useful For

Evaluating patients suspected of having celiac disease, including patients with compatible clinical symptoms, patients with atypical symptoms, and individuals at increased risk (family history, previous diagnosis with associated disease, positivity for HLA DQ2 and/or DQ8)

 

Monitoring adherence to gluten-free diet in patients with dermatitis herpetiformis and celiac disease

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

Tissue Transglutaminase Ab, IgA/IgG

Specimen Type

Serum


Ordering Guidance


Cascade testing is recommended for celiac disease. Cascade testing ensures that testing proceeds in an algorithmic fashion. The following cascades are available; select the appropriate one for your specific patient situation.

-CDCOM / Celiac Disease Comprehensive Cascade: complete testing including HLA DQ

-CDSP / Celiac Disease Serology Cascade: complete testing excluding HLA DQ

-CDGF / Celiac Disease Gluten-Free Cascade: for patients already adhering to a gluten-free diet

To order individual tests, see Celiac Disease Diagnostic Testing Algorithm in Special Instructions.



Specimen Required


Container/Tube: 

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL


Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Reference Values

tTG ANTIBODY, IgA

<4.0 U/mL (negative)

4.0-10.0 U/mL (weak positive)

>10.0 U/mL (positive)

Reference values apply to all ages.

 

tTG ANTIBODY, IgG

<6.0 U/mL (negative)

6.0-9.0 U/mL (weak positive)

>9.0 U/mL (positive)

Reference values apply to all ages.

Day(s) Performed

Monday through Saturday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

83516 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TSTGP Tissue Transglutaminase Ab, IgA/IgG 35681-6

 

Result ID Test Result Name Result LOINC Value
TTGA Tissue Transglutaminase Ab, IgA, S 46128-5
TTGG Tissue Transglutaminase Ab, IgG, S 56537-4

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

Profile Information

Test ID Reporting Name Available Separately Always Performed
TTGA Tissue Transglutaminase Ab, IgA, S Yes Yes
TTGG Tissue Transglutaminase Ab, IgG, S Yes Yes

Report Available

Same day/1 to 4 days

NY State Approved

Yes

Forms

If not ordering electronically, complete, print, and send a Gastroenterology and Hepatology Client Test Request (T728) with the specimen.