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Test ID XL2 FOXL2 Mutation Analysis, Tumor

Advisory Information

At least 20% tumor is required for this assay. The amount of tissue needed is dependent on a variety of preanalytical factors (eg, cellularity, ischemic time, fixation). In general, the minimum specimen adequacy for this test is approximately a 6 mm(2) area of tissue (can be over multiple slides from 1 tissue block) or 5,000 total cells (5,000 total nucleated cells if using cytology slides).

Necessary Information

Pathology report must accompany specimen in order for testing to be performed.

Specimen Required


Specimen Type: Tissue

Container/Tube: Tissue block

Collection Instructions: Submit a formalin-fixed, paraffin-embedded tissue block



Specimen Type: Tissue

Slides: 1 stained and 10 unstained slides

Collection Instructions: Submit 1 slide stained with hematoxylin and eosin and 10 unstained slides (nonbaked, charged slides preferred) with 5-micron thick sections of the tumor tissue.


Specimen Type: Cytology

Container/Tube: Cytology slide (direct smears or ThinPrep)

Slides: 1 to 2 slides (stained and coverslipped) with a minimum of 5,000 total nucleated cells

Collection Instructions: Submit 1 to 2 slides stained and coverslipped

Additional Information: Cytology slides will not be returned.

Useful For

Assisting in the clinical diagnosis of adult granulosa cell tumor (GCT) by assessing gene targets with in the FOXL2 gene

Additional Tests

Test ID Reporting Name Available Separately Always Performed
SLIRV Slide Review in MG No, (Bill Only) Yes

Testing Algorithm

When this test is ordered, slide review will always be performed at an additional charge.

Method Name

Polymerase Chain Reaction (PCR)-Based Next-Generation Sequencing

Reporting Name

FOXL2 Mutation Analysis, Tumor

Specimen Type


Specimen Minimum Volume

See Specimen Required field.

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Ambient (preferred)

Reference Values

An interpretative report will be provided.

Day(s) and Time(s) Performed

Monday through Friday; Varies

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information



LOINC Code Information

Test ID Test Order Name Order LOINC Value
XL2 FOXL2 Mutation Analysis, Tumor In Process


Result ID Test Result Name Result LOINC Value
92373 Result Summary 50397-9
92374 Result 82939-0
92375 Interpretation 69047-9
92376 Additional Information 48767-8
92377 Specimen 31208-2
92378 Source 31208-2
92379 Tissue ID 80398-1
92380 Released By 18771-6

NY State Approved



If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.